Hybrid hydrogels for bioink development and potential use in dental tissue engineering
Keywords:hybrid hydrogel, bioink, tissue engineering
One of the emerging problems in medicine and dentistry today is how to replace and regenerate damaged tissue. Currently used implants are inert and need to be replaced after a certain period. Therefore, the aim is to develop a bioactive multicomponent material that can promote tissue regeneration. Hydrogels are the focus of research in this field because of their similarity to the natural extracellular matrix and their good biocompatibility. Nevertheless, hydrogels often have insufficient mechanical properties for handling and implantation. Therefore, methods of hydrogel reinforcement are developed by adding at least one phase to obtain hybrid hydrogels. There are various methods to reinforce hydrogels, such as functionalization, interpenetrating networks, nanogels, nano-engineered ionic covalent entanglement, etc. The obtained hybrid hydrogel can be used to develop a bioink, a biocompatible and biodegradable material mixed with cells that has suitable properties for 3D bioprinting. The 3D bioprinting method is used to obtain scaffolds of the desired shape and size. Hybrid hydrogel-based 3D printed scaffolds have shown great potential in biological assessment to promote the regeneration of a variety of tissues.
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